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21.01.2017, 08:59 - nieeshoes - Rank 6 - 1073 Posts
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Source: S,
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. Villeda et al/Nature 2011


Those headlines focused on the good news: Young blood rejuvenated old mice. In further studies by other researchers, infusions of young blood made broken bones in old mice heal better (SN Online: 5/19/15),
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, gave their muscles extra spring and improved their memories (SN: 5/31/14, p. cool. Apparently some substances in the blood triggered the rejuvenation. Some candidates for those rejuvenation factors have been identified,
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, although none are universally agreed on.
But news accounts mostly ignored the flip side of the experiment: Being tethered to an old mouse made young mice age faster. One substance in the blood of old mice,
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, a protein called Beta?2?microglobulin, or B2M, seemed to prematurely age the young ones, Villeda and colleagues reported last year in Nature Medicine (SN: 8/8/15, p. 10). Parabiosis experiments don’t last very long,
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, so no one knows whether youth or decrepitude will win in the end?—?or if the two mice would have settled into middle age together.
UCLA’s Horvath has evidence that the mice may never totally sync. He monitors aging by examining molecular tags called methyl groups,
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, which attach to various locations on DNA in a process called methylation. Methylation is an epigenetic modification of DNA. Such modifications work something like flagging passages in a book with sticky notes

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