The diagnosis of this condition is often challenging.Causes There are many possible causes of fatigue including Anemia including iron deficiency anemia Depression or grief Iron deficiency without anemia Medications such as sedatives or antidepressants Persistent pain Sleep disorders such as insomnia obstructive sleep apnea or narcolepsy Thyroid gland that is underactive or overactive Use of alcohol or drugs such as cocaine or narcotics especially with regular use Fatigue can also occur with the following illnesses Addison disease Anorexia nervosa or other eating disorders Arthritis including juvenile rheumatoid arthritis Autoimmune diseases such as systemic lupus erythematosus Cancer Congestive heart failure Diabetes Fibromyalgia Infection especially one that takes a long time to recover from or treat such as bacterial endocarditis infection of the heart muscle or valves parasitic infections hepatitis human immunodeficiency virus HIV AIDS tuberculosis and mononucleosis Kidney disease Liver disease Malnutrition Certain medications may also cause drowsiness or fatigue including antihistamines for allergies blood pressure medicines sleeping pills steroids and diuretics.At the time of our final literature search studies directly comparing these drugs had not been published.
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