The present crosssectional study was designed to evaluate Serum sex hormone levels as markers of hypothalamicpituitarygonadal axis dysfunction in men with stable moderatetosevere COPD to compare with those of agematched control subjects with normal pulmonary function The hormonal status during an acute exacerbation of COPD and followup after exacerbation phase The determinants of the alterations in sex hormones in COPD smoking body mass index pulmonary function exacerbation of disease severity of hypoxaemia and hypercapnia The relationship between markers of systemic inflammation IL and TNF and hypogonadism in COPD Methods Patients A total of consecutive male COPD patients who attended chest diseases outpatient clinic were asked to participate in the study.
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