Epigenetic therapeutics that have been developed with the purpose to exert epigenetic effects Substance Chemical class Target Epigenetic consequences Indications Refs Epigenetic therapeutics Suberoylanilide hydroxamic acid SAHA vorinostat Hydroxamic acids HDACs Histone acetylation Advanced cutaneous T cell lymphoma CTCL FDAapproved PXD belinostat Hepatocellular carcinoma Phase III ITF givinostat Hematological malignancies Phase II Systemiconset juvenile idiopathic arthritis SOJIA Phase I Depsipeptide Romidepsin Cyclic peptides Advanced cutaneous T cell lymphoma CTCL and peripheral T cell lymphoma FDAapproved MS entinostat Benzamides Solid tumors Phase III Azacytidine AzaCR Vidaza Nucleoside analogs DNMTs DNA hypomethylation Myeloid malignancies FDAapproved Aza deoxycytidine AzaCdR Decitabine Epigenetic effects of drugs with structural similarities to epigenetic factors are highly likely as shown for valproic acid which besides exerting channel blocking actions is also a HDAC inhibitorAbsence of significant hypervolemia e.
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